Fibrillin-1 Interactions with Heparin
نویسندگان
چکیده
منابع مشابه
Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly.
Fibrillin-1 assembly into microfibrils and elastic fiber formation involves interactions with glycosaminoglycans. We have used BIAcore technology to investigate fibrillin-1 interactions with heparin and with heparin saccharides that are analogous to S-domains of heparan sulfate. We have identified four high affinity heparin-binding sites on fibrillin-1, localized three of these sites, and defin...
متن کاملFibrillin-1 Interactions with Heparin: Implications for Microfibril and Elastic Fibre Assembly *
Fibrillin-1 assembly into microfibrils and elastic fiber formation involve interactions with glycosaminoglycans. We have used BIAcore technology to investigate fibrillin-1 interactions with heparin, and with heparin saccharides that are analogous to S-domains of heparan sulfate. We have identified four high affinity heparin binding sites on fibrillin-1, localized three of these sites, and defin...
متن کاملFibrillin-integrin interactions in health and disease.
Human fibrillin-1 is the major structural protein of extracellular matrix 10-12 nm microfibrils. It has a disulfide-rich modular organization which consists primarily of cbEGF (Ca(2+)-binding epidermal growth factor-like) domains and TB (transforming growth factor beta-binding protein-like) domains. TB4 contains an RGD (Arg-Gly-Asp) integrin-binding motif. The atomic structure of this region ha...
متن کاملMicroenvironmental Regulation by Fibrillin-1
Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue microenvironments has not been elucidated, even though the concept that fibrillin-1 provides extracellular control of growth factor signaling is currently appreciated. Mutations in FBN1 are mainly responsible for the Marfan syndrome (MFS), recogni...
متن کاملHeparan sulfate and heparin interactions with proteins.
Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and extracellular matrix of all multicellular animals, whereas heparin is present within mast cells and can be viewed as a more sulfated, tissue-specific, HS variant. HS and heparin regulate biological processes through interactions with a large repertoire of proteins. Owing to these interactions and diverse effe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m501390200